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. 2009 Feb 6;9:9. doi: 10.1186/1471-213X-9-9

Figure 1.

Figure 1

Identification of an allele-specific single nucleotide polymorphism (SNP) on SNRPN exon 2. Schematic representation of the bicistronic SNURF-SNRPN locus in Bos indicus and Bos taurus, depicting the progression from DNA to protein. Genomic: Numbered boxes represent exons respective to SNURF (black) and SNRPN (gray); hatched box represents the DMR analyzed. Primer positions and amplicon size for DMR and allele-specific cDNA are indicated above. mRNA: Single transcript with the SNURF (black) and SNRPN (gray) open reading frames. Bos taurus and Bos indicus cDNA sequences are aligned to indicate the SNP (G to A transition; open box) at position +151 (GeneBank AF1010140). Protein: Amino acid alignment of SNURF protein is shown for Bos taurus, Bos indicus and compared to a consensus sequence. Differences from the consensus are indicated in white boxes. The Bos indicus SNP leads to a change from an aspergine to a serine in the phosphorylation site for casein kinase II (CK2) (adapted from [19]).