Table 1.

Summary of 22 placebo-controlled clinical trials of venlafaxine for treatment of major depressive disorder^a

Study no.	IR/ER	Fixed/flexible Dosing	Dose range (mg/day)	Practice setting	Duration (weeks)	Median baseline HAM-D17
014 [11]	IR	Fixed	75, 150, 225	Outpatient	6	21
015 [12]	IR	Fixed	75, 150, 225	Outpatient	8	21
016 [10]	IR	Flexible	37.5 to 375	Inpatient	6	26
203 [16]	IR	Fixed ranges	75, 150 to 225, 300 to 375	Outpatient	6	22
206 [23]	IR	Flexible	150 to 375	Inpatient	4	27
208 [14]	IR and ER	Flexible	IR: 75 to 150; ER: 75 to 150	Outpatient	12	22
209 [15]	ER	Flexible	75 to 225	Outpatient	8	21
211 [13]	ER	Flexible	75 to 225	Outpatient	8	22.5
300	IR	Flexible	150 to 375	Inpatient	6	29
301	IR	Flexible	75 to 225	Outpatient	6	22
302 [17]	IR	Flexible	75 to 200	Outpatient	6	22
303 [18]	IR	Flexible	75 to 225	Outpatient	6	22
313 [19]	IR	Fixed ranges	25, 50 to 75, 150 to 200	Outpatient	6	23
341	IR	Flexible	100 to 200	Outpatient	52	22
342 [20]	IR	Fixed	75, 150, 200	Outpatient	12	22
343	IR	Fixed ranges	100 to 150, 175 to 225	Outpatient	14	20
360 [21]	ER	Flexible	75 to 225	Outpatient	12	25
367 [22]	ER	Fixed	75, 150	Outpatient	8	25
372	IR	Flexible	200 to 375	Outpatient	6	22
384	ER	Flexible	150 to 375	Outpatient	6	25
402	ER	Flexible	37.5 to 300	Outpatient	10	23
414	ER	Flexible	37.5 to 300	Outpatient	10	22

ER, extended release; HAM-D₁₇, 17-item Hamilton Depression Rating Scale; IR, immediate release.

^aData on File at Wyeth Research. 2006.