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CRABP1 was up-regulated specifically for an increased Aβ42/Aβ40 ratio demonstrated by 2D-DIGE. Two-dimensional polyacrylamide gel electrophoresis of CyDye-labeled proteins, extracted from SH-SY5Y cells. C99I45F and C99V50F were compared with C99WT. Differentially expressed proteins, evaluated by intensity of merged colors (Cy5, Cy3), were identified by mass spectrometry. Arrows indicate CRABP1.
