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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Genomics. 2008 Oct 25;93(1):62–71. doi: 10.1016/j.ygeno.2008.09.002

Fig. 9.

Fig. 9

Effect RARα siRNA knockdown on the activity of MSRA promoters. D407 cells were co-transfected with promoter 1 and promoter 2 luciferase reporter constructs (1–2 and 2–3, respectively) and a siRNA for RARα or a negative siRNA control. The RARα siRNA knocks down approximately 70% of the native RARα mRNA levels. After the co-transfection (24 h), the cells were treated with 0.5, 1 and 5 μM ATRA and luciferase activity was measured 24 h after the ATRA treatment. A Promoter 1 response. B. Promoter 2 response.