NUDR protein levels in PFC of 13 female (A, B) and 12 male (C, D) control and MDD subjects expressed as the mean ± SEM of NUDR/actin R.O.D. Data were analyzed using a maximum likelihood mixed models test. Female subject groups: control subjects (0.89 ± 0.16) compared to the matched MDD subjects (0.52 ± 0.08, t12=2.64, *P=0.022). Male subject groups: control subjects (0.51 ± 0.11) compared to the matched MDD subjects (0.47 ± 0.06, t10.2=0.33, P=0.474). NUDR levels in PFC of female (B) and male (D) depressive subjects expressed as percentage of values from paired control subjects.