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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: J Vasc Res. 2008 Sep 2;46(2):119–137. doi: 10.1159/000151766

Figure 5. Potential mechanism for enhancement of TGF-β signaling in the presence of non-functional receptors.

Figure 5

Ligand-induced receptor signaling complexes that are unable to transmit signals because of mutations within the receptor kinase domain (TGF-βRII/TGF-βRI/both), may still function by seeding active signaling platforms that localize other signaling components capable of inducing downstream signaling events that contribute to aneurysm development.