Fig. 2.

Proposed indapamide metabolic pathways catalyzed by human liver microsomes or CYP3A4 (M1–M5) in the presence of microsomal epoxide hydrolase (M6) or glutathione (M7). To simplify the figure, single regioisomers are shown for the epoxide, phenol, diol, and glutathione adduct structures. However, the sites of substitution on the phenyl or cyclohexadiene rings were not established. The putative epoxide reactive intermediate is shown with brackets. EH, microsomal epoxide hydrolase; GSH, glutathione.