TABLE 1.

Pharmacokinetic parameters for nifedipine clearance

Blood NFP levels (from Fig. 6) were used to calculate pharmacokinetic parameters, including AUC, T_max (the time at which maximum concentration occurs), C_max (the maximum concentration), and t_1/2 (the elimination half-life). Values presented are mean ± S.D. (n = 6 for oral and n = 4 for intravenous administration). Student's t test was used for statistical analysis of differences between WT and IE-Cpr-null strains.

Strain	Treatment Route	Tmax	Cmax	t1/2	AUC0-∞
		h	nmol/ml	h	nmol · h/ml
WT	Oral	0.50	4.9 ± 1.2	1.38 ± 0.74	8.0 ± 0.5
IE-Cpr-null	Oral	0.50	9.0 ± 2.5a	0.91 ± 0.26	12.8 ± 2.3a
WT	Intravenous	0.17	6.6 ± 1.5	0.23 ± 0.02	3.6 ± 0.8
IE-Cpr-null	Intravenous	0.17	6.6 ± 0.9	0.26 ± 0.05	3.8 ± 0.6

AUC, area under the concentration-time curve.

^ap < 0.01, as compared with similarly treated WT mice.