Figure 1.

Predicted amino acid sequence of human prepro-memapsin 1 (GenBank accession no. AF200192) and prepro-memapsin 2 (GenBank accession no. AF200193) aligned against the sequence of human pre-pepsinogen. Amino acid codes are according to standard International Union of Pure and Applied Chemistry nomenclature. The beginning of pro and mature protease regions of pepsinogen are marked by residue numbers 1P and 1, respectively. Two active-site aspartic acids in D(T/S)G motifs are marked by ■ and conserved Tyr⁷⁵ by ♦. Residues in the predicted transmembrane domains are in boldface.