Fig. (4).Phosphorylation sites of NMDAR subunits.

The N-methyl-D-aspartate (NMDA) receptor subunits are phosphorylated on serine and tyrosine residues. Depicted are the amino acid sequences of the cytoplasmic tails of rat NR1, NR2A, and NR2B subunits. The N-terminus faces the membrane, and the C terminus is facing inward. The kinase is depicted on the top of each rectangle, and the amino acid residue is depicted at the bottom. PKC, protein kinase C;PKA, protein kinase A.

(Adapted from: Ron, D. (2004) Signaling Cascades Regulating NMDA Receptor Sensitivity to Ethanol. Neuroscientist, 10(4), 325-336.)