Fig. (5)Schematic depiction of the timeline of changes in GABA_A receptor subunit mRNA expression in the hippocampus, in rodent models of temporal lobe seizures and epilepsy.

The effects of SE change according to age of induction, model, and species. In most cases, the results stem from the lithium-pilocarpine or pilocarpine SE model, except for the results marked with an asterisk, which were described after kainic acid SE. Adulthood starts at PN60. The time scale used for the effects of SE in adult rats is approximate and is meant to reflect changes during the latent phase of epileptogene-sis, prior to the onset of spontaneous seizures, and during the epileptic phase, ie after the occurrence of 2 spontaneous seizures. The diagrams are based on a review of the pertinent literature [33, 73, 163, 254, 244, 345].