Table 1.

Distribution of TRPV1, TRPV2, TRPA1, TRPM8, TRPV3 and TRPV4

ThermoTRP	Neuronal Distribution	Non-Neuronal Distribution
TRPV1	dorsal root ganglia; trigeminal ganglia; jugular ganglia; nodose ganglia; solitary tract nucleus; trigeminal nucleus; ventral medulla; periaqueductyl grey; dorsal raphe nucleus; locus coeruleus; hypothalamus; thalamus; hippocampus; ventral tegmental area; cerebel-lum; substantia nigra; somatosensory cortex	epithelial cells of the GI, airway and bladder; epidermal keratinocytes from human skin; enterocytes; liver; vascular endothelium; mast cells; smooth muscle; fibroblasts; peripheral mononuclear blood cells.
TRPV2	dorsal root ganglia; trigeminal ganglia; nodose ganglia; spinal cord Lissauer's tract, dorsal column nuclei, posterior column, ventral horn, motoneurons, sympathetic preganglionic neurons, central canal ependymal; hypothalamic paraventricular nuclei, suprachiasmatic nuclei, supraoptic nuclei, oxytocinergic and vasopressinergic neurons; cerebral cortex	vascular and cardiac myocytes; mast cells; astrocytes; spleen; lung; intestine; vas deferens
TRPA1	dorsal root ganglia; nodose ganglia; trigeminal ganglia; superior cervical ganglion; geniculate ganglia	lung fibroblasts; hair cell stereocilia; intestine; skeletal muscle; heart; immune system
TRPM8	dorsal root ganglia; trigeminal ganglia; nodose ganglia	prostate; urogenital tract; taste papillae; testis; scrotal skin; bladder urothelium; thymus; breast; ileum;
TRPV3	dorsal root ganglia; motor neurons; superior cervical ganglia; nigral dopaminergic neurons	keratinocytes; hair follicle sheath cells; skeletal muscle; pituitary; intestine
TRPV4	dorsal rrot ganglia; trigeminal ganglia; circumventricular organs; choroids plexus; cerebral cortex; thalamus; hippocampus; cerebellum; hypothalamus	vascular aortic endothelium; blood–brain barrier endothelium; renal collecting duct; vascular smooth muscle; cochlea; keratinocytes