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Cell Signaling Modulators of TRPV1, TRPV2, TRPA1, TRPM8, TRPV3 and TRPV4
| ThermoTRP | +ve Modulators | -ve Modulators |
|---|---|---|
| TRPV1 | PKC, PKA, CAMKII, ERK, PI3K | calcineurin, calmodulin; PIP2 |
| TRPV2 | IGF-I; AKAP/cAMP/PKA; PI3K; CAMK | |
| TRPA1 | p38 MAPK; ERK; PLC; Artemin | pyrophosphate (PPi); polytriphosphate (PPPi) |
| TRPM8 | PIP2; calcium | PKC; PKA |
| TRPV3 | arachidonic acid and metabolites; PKC | |
| TRPV4 | Src-tyrosine kinase; AQP5; PACSINs; MAP7 | WNK1; WNK4 |
