Table 3. TRPM8.
| Compound | Structure | Origin | Action | Conc. Range |
|---|---|---|---|---|
| Menthol |  |
Mentha genus | Activates (68, 91) | 10-5 - 10-3 M |
| Eucalyptol |  |
Eucalyptus polybractea | Activates (8) | 10-4 - 10-2 M |
| Menthone |  |
Precursor in menthol biosynthesis | Activates (68) | 10-4 - 10-3 M |
| Geraniol |  |
Cymbopogon nardus | Activates (8) | 10-2 - 10-3 M |
| Linalool |  |
Onagraceae genus | Activates (8) | 10-2 - 10-3 M |
| Menthyl lactate |  |
Peppermint oil | Activates (6) | 10-4 - 10-3 M |
| Cis- and trans-p-menthane3,8-diol |  |
Eucalyptus citriodora | Activates (6) | 10-4 - 10-3 M |
| L-carvone |  |
Mentha spicata | Activates (6) | 10-4 - 10-3M |
| Isopulegol |  |
Mentha pulegium or Lelium ledebourii | Activates (6) | 10-4 - 10-3 M |
| Hydroxyl-citronellal |  |
Citronella oil | Activates(8) | 10-2 -10-3M |
| Eugenol |  |
Clove oil | Activates (8) but also TRPA1 (6) and TRPV1 (137) | 10-3 – 10-4 M |
| Cinnamaldehyde |  |
Cinnamomum cassia or Cinnamomum zeylanicum | Inhibits (65) | 10-2 - 10-3 M |
| Ethanol |  |
Inhibits by modulating PiP2 interaction (9) | 0.1 – 1 M |