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Effects of Ro 25-6981 on exploratory locomotion and anxiety-like behavior. In the novel open field, Ro 25-6981 did not alter total distance traveled (A), while the highest dose decreased percent center time (B) (n=10/dose). In the elevated plus-maze, Ro 25-6981 did not alter time spent in the open arms, center square or closed arms (C), or open, closed or total arm entries (D) (n=11/dose). **p<.01 vs. vehicle (0).
