Table 1.

Recipient-, Donor-, and Transplant-Related Variables for 1960 HLA-Identical Sibling Transplants for Leukemia (AML, ALL, CML), Between 1995 and 2002 and Reported to the Center for International Blood and Marrow Transplant Research by 226 Teams Worldwide

Variable	No. Assessable	1995-1998		No. Assessable	1999-2002		P
		No.	%		No.	%
Recipient age, years	1,298			662			.7235
Median		37			37
Range		18-69			18-67
18-39		749	58		377	57	.7490
≥ 40		549	42		285	43
Donor age, years	1,284			657			.6068
Median		36			36
Range		< 1-73			< 1-72
0-9		9	1		12	2	.2063
10-19		103	8		56	9
20-29		259	20		138	21
30-39		406	31		185	28
40-49		320	25		167	25
≥ 50		187	14		99	15
Donor-recipient sex match	1,298			662			.1075
Male → Male		448	35		230	35
Male → Female		363	28		160	24
Female → Male		252	19		156	24
Female → Female		235	18		116	18
Karnofsky performance score	1,298			662			.1650
0-80		282	22		126	19
90-100		1016	78		536	81
Leukemia type	1,298			662			.0279
Acute myeloid leukemia		493	38		268	40
Acute lymphoblastic leukemia		186	14		117	18
Chronic myeloid leukemia		619	48		277	42
Leukemia status prior to HSCT	1,298			662			.0127
Early		973	75		455	69
Intermediate		182	14		119	18
Advanced		143	11		88	13
Race	1,298			662			.4911
White		1022	79		526	79
Black		33	3		10	2
Asian		168	13		84	13
Hispanic		75	6		42	6
Recipient-donor cytomegalovirus status	1,298			662			.0393
Recipient–/donor–		376	29		158	24
Recipient+/donor–		175	13		105	16
Recipient–/donor+		134	10		59	9
Recipient+/donor+		613	47		340	51
Donor pregnancy	1,298			662			.3079
Female, No		178	14		100	15
Female, Yes		309	24		172	26
Male		811	62		390	59
Graft type	1,298			662			< .0001
Bone marrow		963	74		314	47
Peripheral blood		335	26		348	53
Time from diagnosis to HSCT, months	1,298			662			.1555
Median		7			7
Range		1-655			< 1-207

Abbreviations: HLA, human leukocyte antigen; AML, acute myeloid leukemia; ALL, acute lymphoblastic leukemia; CML, chronic myeloid leukemia; HSCT, hematopoietic stem-cell transplantation.