Table 2.
Multivariable Analysis of Risk Factors for Grade 2-4 Acute Graft-Versus-Host Disease
| Variable | RR | 95% CI | P |
|---|---|---|---|
| For recipients age 18-39 years | |||
| Bone marrow graft | 1.0 | ||
| Peripheral blood stem-cell graft | 1.43 | 1.14 to 1.79 | .0023 |
| For recipients age 40+ years | |||
| Bone marrow graft | 1.0 | ||
| Peripheral blood stem-cell graft | 0.98 | 0.78 to 1.23 | .8528 |
| Age for recipients of bone marrow transplants, years | |||
| 18-39 | 1.0 | ||
| 40+ | 1.44 | 1.17 to 1.77 | .0005 |
| Age for recipients of peripheral-blood stem-cell transplants, years | |||
| 18-39 | 1.0 | ||
| 40+ | 0.99 | 0.77 to 1.27 | .9273 |
| Race | |||
| Asian/Hispanic | 1.0 | ||
| White/Black | 1.54 | 1.22 to 1.94 | .0003 |
| Leukemia type | |||
| Acute myeloid or lymphoblastic leukemia | 1.0 | ||
| Chronic myeloid leukemia | 1.35 | 1.15 to 1.59 | .0003 |
| Karnofsky performance score at transplant | |||
| 90-100 | 1.0 | ||
| 0-80 | 1.27 | 1.05 to 1.53 | .0144 |
| Conditioning regimen | |||
| BuCy ± other | 1.0 | ||
| CyTBI ± other | 1.40 | 1.19 to 1.66 | < .0001 |
| Recipient-donor cytomegalovirus status | |||
| ≥ 1 positive | 1.0 | ||
| Both negative | 1.20 | 1.01 to 1.42 | .0415 |
Abbreviations: RR, relative risk; BuCy ± other, busulfan and cyclophosphamide with or without additional agents; CyTBI ± other, cyclophosphamide and total body irradiation with or without additional agents.