Table 3.

Validation of Final Multivariable Model for Grade 3-4 Acute Graft-Versus-Host Disease

Variable	RR	95% CI	P
For recipients age 18-39 years
Bone marrow graft	1.0
Peripheral blood stem-cell graft	1.51	1.07 to 2.14	.0201
For recipients age 40+ years
Bone marrow graft	1.0
Peripheral blood stem-cell graft	1.31	0.94 to 1.83	.1091
Age for recipients of bone marrow transplants, years
18-39	1.0
40+	1.43	1.04 to 1.96	.0280
Age for recipients of peripheral-blood stem-cell transplants, years
18-39	1.0
40+	1.24	0.86 to 1.79	.2492
Race
Asian/Hispanic	1.0
White/Black	1.03	0.75 to 1.41	.8736
Leukemia type
Acute myeloid or lymphoblastic leukemia	1.0
Chronic myeloid leukemia	1.32	1.03 to 1.69	.0261
Karnofsky performance score at transplant
90-100	1.0
0-80	1.47	1.12 to 1.93	.0063
Conditioning regimen
BuCy ± other	1.0
CyTBI ± other	0.99	0.77 to 1.27	.9127
Recipient-donor cytomegalovirus status
≥ 1 positive	1.0
Both negative	1.33	1.03 to 1.71	.0308

Abbreviations: RR, relative risk; BuCy ± other, busulfan and cyclophosphamide with or without additional agents; CyTBI ± other, cyclophosphamide and total body irradiation with or without additional agents.