Table 2.
Serum factors names, abbreviations, and functions
| Functional group |
Serum factor |
|||
|---|---|---|---|---|
| Abbreviation | Full name | Analyzed | Reported function | |
| Cytokine/Chemokine | Eotaxin | Eotaxin-1 | X | Attracts eosionophils |
| IFN-α | Interferon-alpha | – | Activates macrophages and NK | |
| IFN-γ | Interferon-gamma | – | Induced by foreign macromolecules | |
| IL-10 | Interleukin-10 | – | Reduces cytokine/chemokine production | |
| IL-12 p40 | Interleukin-12 p40 subunit | X | Stimulates NK to produce IFN-g | |
| IL-13 | Interleukin-13 | X | Induces IgE | |
| IL-15 | Interleukin-15 | X | Induces proliferation of NK | |
| IL-17 | Interleukin-17 | – | Proinflamatory | |
| IL-1α | Interleukin-1-alpha | X | Stimulates immune, inflammatory, and hematopoetic response | |
| IL-1β | Interleukin-1-beta | – | COX2 upregulation | |
| IL-2 | Interleukin-2 | – | Stimulates CD4 | |
| IL-4 | Interleukin-4 | X | B and T cell differentiation | |
| IL-5 | Interleukin-5 | X | Promotes B cells and IgA | |
| IL-6 | Interleukin-6 | X | Acute phase response, produced by macrophages | |
| IL-7 | Interleukin-7 | – | Lymphoid progenitor proliferation | |
| IL-8 | Interleukin-8 | X | Recruits PMNs | |
| IP-10 | Interferon gamma inducible protein 10 | X | Induced by IFN | |
| MCP-1 | Monocyte chemotactic protein alpha | – | Chemotaxis | |
| MIG | Monocyte induced gamma interferon | X | Cell migration | |
| MIP-1α | Macrophage inflammatory protein 1-alpha | X | Activates granulocytes | |
| MIP-1β | Macrophage inflammatory protein 1-beta | – | See above | |
| RANTES | Regulated upon activation, normally T-expressed and presumably secreted | X | Chemotactic for T cells, eosinophils, basophils, leukocytes | |
| TNF-α | Tumor necrosis factor alpha | X | Produced by macrophages | |
| TNF-RI | Tumor necrosis factor Receptor I | X | TNF receptor | |
| TNF-RII | Tumor necrosis factor Receptor II | X | TNF receptor | |
| Growth or Angiogenic | DR5 | Death receptor 5 | – | Transduces apoptosis |
| EGF | Epithelial growth factor | X | Promotes epithelial cells | |
| bFGF | Basic fibroblast growth factor | – | Promotes fibroblasts | |
| G-CSF | Granulocyte colony stimulating factor | X | Promotes granulocytes | |
| GM-CSF | Granulocyte monocyte colony stimulating factor | – | Promotes granulocytes and monocytes | |
| HGF | Hepatocyte growth factor | X | Promotes hepatocytes | |
| VEGF | Vascular endothelial growth factor | – | Vasculogenesis and angiogenesis | |