Table 3.
No Diabetes Mellitus |
Diabetes Mellitus |
|||||
---|---|---|---|---|---|---|
Nerve Function | No PAD (n = 225) | PAD (n = 321) | P Value | No PAD (n = 67) | PAD (n = 157) | P Value |
Unadjusted Analyses* | ||||||
Peroneal NCV, m/s | 45.2 (4.6) | 43.8 (4.8) | .002 | 43.0 (5.6) | 41.1 (5.5) | .04 |
Peroneal nerve amplitude, μV | 3.95 (4.68) | 3.14 (2.26) | .01 | 2.69 (2.22) | 2.11 (2.15) | .08 |
Peroneal nerve latency, ms | 4.62 (0.77) | 4.84 (0.80) | .003 | 4.99 (1.49) | 5.19 (1.44) | .41 |
Sural nerve NCV, m/s | 45.1 (6.8) | 42.2 (6.9) | <.001 | 44.4 (9.1) | 42.0 (9.2) | .21 |
Sural nerve amplitude, μV | 6.77 (5.53) | 5.65 (5.91) | .03 | 4.03 (4.76) | 3.50 (4.85) | .48 |
Sural nerve latency, ms | 3.17 (0.49) | 3.47 (1.26) | .005 | 3.36 (1.18) | 4.31 (7.53) | .47 |
Ulnar NCV, m/s | 53.1 (5.75) | 52.1 (5.02) | .04 | 50.0 (5.65) | 47.8 (7.40) | .04 |
Ulnar sensory amplitude, μV | 20.9 (12.5) | 17.7 (10.9) | .002 | 15.0 (10.5) | 13.5 (12.4) | .40 |
Ulnar sensory latency, ms | 2.68 (0.47) | 2.72 (0.27) | .31 | 2.84 (0.35) | 3.02 (0.63) | .04 |
| ||||||
Adjusted Analyses† | ||||||
Peroneal NCV, m/s | 44.7 (0.34) | 44.2 (0.28) | .28 | 43.5 (0.77) | 40.8 (0.50) | .01 |
Peroneal nerve amplitude, μV | 3.8 (0.28) | 3.3 (0.22) | .20 | 2.7 (0.32) | 2.1 (0.20) | .14 |
Peroneal nerve latency, ms | 4.7 (0.06) | 4.8 (0.05) | .29 | 4.9 (0.23) | 5.2 (0.15) | .32 |
Sural nerve NCV, m/s | 44.2 (0.61) | 42.9 (0.51) | .14 | 45.5 (1.92) | 41.3 (1.23) | .11 |
Sural nerve amplitude, μV | 6.2 (0.44) | 6.0 (0.35) | .75 | 4.8 (0.63) | 3.1 (0.39) | .045 |
Sural nerve latency, ms | 3.3 (0.09) | 3.4 (0.08) | .39 | 2.4 (1.39) | 4.8 (0.89) | .21 |
Ulnar NCV, m/s | 52.5 (0.40) | 52.4 (0.32) | .95 | 50.2 (0.91) | 47.6 (0.56) | .03 |
Ulnar sensory amplitude, μV | 18.9 (0.79) | 19.0 (0.63) | .92 | 15.1 (1.56) | 13.6 (0.96) | .46 |
Ulnar sensory latency, ms | 2.7 (0.03) | 2.7 (0.02) | .93 | 2.9 (0.08) | 3.0 (0.05) | .11 |
Abbreviations: ms, milliseconds; NCV, nerve conduction velocity; PAD, peripheral arterial disease.
Unadjusted data are given as mean (SD) unless otherwise specified.
Adjusted for age, sex, body mass index, race, cigarette smoking, comorbidities, height, alcohol consumption, recruitment cohort, lower extremity revascularization. Adjusted data are given as mean (SE) unless otherwise specified.