Table 3.
Nerve Function According to Presence vs Absence of PAD Among 770 Participants With and Without Diabetes Mellitus
| No Diabetes Mellitus |
Diabetes Mellitus |
|||||
|---|---|---|---|---|---|---|
| Nerve Function | No PAD (n = 225) | PAD (n = 321) | P Value | No PAD (n = 67) | PAD (n = 157) | P Value |
| Unadjusted Analyses* | ||||||
| Peroneal NCV, m/s | 45.2 (4.6) | 43.8 (4.8) | .002 | 43.0 (5.6) | 41.1 (5.5) | .04 |
| Peroneal nerve amplitude, μV | 3.95 (4.68) | 3.14 (2.26) | .01 | 2.69 (2.22) | 2.11 (2.15) | .08 |
| Peroneal nerve latency, ms | 4.62 (0.77) | 4.84 (0.80) | .003 | 4.99 (1.49) | 5.19 (1.44) | .41 |
| Sural nerve NCV, m/s | 45.1 (6.8) | 42.2 (6.9) | <.001 | 44.4 (9.1) | 42.0 (9.2) | .21 |
| Sural nerve amplitude, μV | 6.77 (5.53) | 5.65 (5.91) | .03 | 4.03 (4.76) | 3.50 (4.85) | .48 |
| Sural nerve latency, ms | 3.17 (0.49) | 3.47 (1.26) | .005 | 3.36 (1.18) | 4.31 (7.53) | .47 |
| Ulnar NCV, m/s | 53.1 (5.75) | 52.1 (5.02) | .04 | 50.0 (5.65) | 47.8 (7.40) | .04 |
| Ulnar sensory amplitude, μV | 20.9 (12.5) | 17.7 (10.9) | .002 | 15.0 (10.5) | 13.5 (12.4) | .40 |
| Ulnar sensory latency, ms | 2.68 (0.47) | 2.72 (0.27) | .31 | 2.84 (0.35) | 3.02 (0.63) | .04 |
|
| ||||||
| Adjusted Analyses† | ||||||
| Peroneal NCV, m/s | 44.7 (0.34) | 44.2 (0.28) | .28 | 43.5 (0.77) | 40.8 (0.50) | .01 |
| Peroneal nerve amplitude, μV | 3.8 (0.28) | 3.3 (0.22) | .20 | 2.7 (0.32) | 2.1 (0.20) | .14 |
| Peroneal nerve latency, ms | 4.7 (0.06) | 4.8 (0.05) | .29 | 4.9 (0.23) | 5.2 (0.15) | .32 |
| Sural nerve NCV, m/s | 44.2 (0.61) | 42.9 (0.51) | .14 | 45.5 (1.92) | 41.3 (1.23) | .11 |
| Sural nerve amplitude, μV | 6.2 (0.44) | 6.0 (0.35) | .75 | 4.8 (0.63) | 3.1 (0.39) | .045 |
| Sural nerve latency, ms | 3.3 (0.09) | 3.4 (0.08) | .39 | 2.4 (1.39) | 4.8 (0.89) | .21 |
| Ulnar NCV, m/s | 52.5 (0.40) | 52.4 (0.32) | .95 | 50.2 (0.91) | 47.6 (0.56) | .03 |
| Ulnar sensory amplitude, μV | 18.9 (0.79) | 19.0 (0.63) | .92 | 15.1 (1.56) | 13.6 (0.96) | .46 |
| Ulnar sensory latency, ms | 2.7 (0.03) | 2.7 (0.02) | .93 | 2.9 (0.08) | 3.0 (0.05) | .11 |
Abbreviations: ms, milliseconds; NCV, nerve conduction velocity; PAD, peripheral arterial disease.
*
Unadjusted data are given as mean (SD) unless otherwise specified.
†
Adjusted for age, sex, body mass index, race, cigarette smoking, comorbidities, height, alcohol consumption, recruitment cohort, lower extremity revascularization. Adjusted data are given as mean (SE) unless otherwise specified.