Table 3.
Odd ratios (OR) and 95% CIs for multivariate relations between selenium concentration and low hip, knee, and grip strength
| Low hip strength |
Low knee strength |
Low grip strength |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Characteristic | OR | 95% CI | P | OR | 95% CI | P | OR | 95% CI | P |
| Model 11 | |||||||||
| Plasma selenium (μmol/L)2,3 | |||||||||
| Quartile 1, <0.8 μmol/L | 1.55 | 0.95, 2.54 | 0.08 | 1.82 | 1.09, 3.02 | 1.76 | 1.10, 2.82 | 0.02 | |
| Quartile 2, 0.8–0.9 μmol/L | 1.61 | 0.99, 2.64 | 0.06 | 1.40 | 0.83, 2.37 | 1.09 | 0.66, 1.78 | 0.73 | |
| Quartile 3, 0.9–1.0 μmol/L | 1.11 | 0.66, 1.85 | 0.69 | 1.39 | 0.83, 2.37 | 0.86 | 0.52, 1.43 | 0.56 | |
| Quartile 4, >1.0 μmol/L | 1.00 | — | — | 1.00 | — | — | 1.00 | — | — |
| Age (y) | 1.12 | 1.09, 1.15 | <0.0001 | 1.09 | 1.07, 1.12 | <0.0001 | 1.11 | 1.08, 1.14 | <0.0001 |
| Sex (female) | 0.63 | 0.50, 1.07 | 0.10 | 0.89 | 0.61, 1.32 | 0.59 | 0.77 | 0.53, 1.12 | 0.18 |
| Education (y) | 0.96 | 0.91, 1.02 | 0.17 | 0.93 | 0.87, 0.99 | 0.01 | 0.99 | 0.93, 1.04 | 0.61 |
| BMI (kg/m2) | 0.95 | 0.91, 0.99 | 0.03 | 0.99 | 0.95, 1.03 | 0.66 | 0.95 | 0.91, 0.99 | 0.02 |
| Total energy intake (kcal/d) | 1.00 | 0.99, 1.00 | 0.08 | 1.00 | 1.00, 1.00 | 0.74 | 1.00 | 0.99, 1.00 | 0.09 |
| Model 24 | |||||||||
| Plasma selenium (μmol/L)2,5 | |||||||||
| Quartile 1, <0.8 μmol/L | 1.69 | 1.02, 2.83 | 0.04 | 1.94 | 1.18, 3.19 | 0.009 | 1.94 | 1.19, 3.16 | |
| Quartile 2, 0.8–0.9 μmol/L | 1.78 | 1.08, 2.94 | 0.02 | 1.34 | 0.82, 2.22 | 0.24 | 1.24 | 0.76, 2.03 | |
| Quartile 3, 0.9–1.0 μmol/L | 1.36 | 0.81, 2.26 | 0.24 | 1.28 | 0.78, 2.19 | 0.35 | 0.90 | 0.54, 1.51 | |
| Quartile 4, >1.0 μmol/L | 1.00 | — | — | 1.00 | — | — | 1.00 | — | — |
| Age (y) | 1.10 | 1.07, 1.13 | <0.0001 | 1.09 | 1.06, 1.12 | <0.0001 | 1.09 | 1.07, 1.13 | <0.0001 |
| Sex (female) | 0.66 | 0.44, 0.98 | 0.04 | 1.01 | 0.68, 1.58 | 0.98 | 0.66 | 0.44, 0.97 | 0.43 |
| Education (y) | 0.99 | 0.94, 1.05 | 0.70 | 0.94 | 0.88, 1.00 | 0.05 | 0.98 | 0.92, 1.04 | 0.43 |
| BMI (kg/m2) | 0.96 | 0.91, 1.01 | 0.06 | 1.01 | 0.97, 1.05 | 0.73 | 0.95 | 0.91, 0.99 | 0.03 |
| Total energy intake (kcal/d) | 1.00 | 0.99, 1.00 | 0.04 | 1.00 | 1.00, 1.00 | 0.91 | 1.00 | 0.99, 1.00 | 0.07 |
| Congestive heart failure | 1.02 | 0.83, 1.25 | 0.87 | 0.93 | 0.75, 1.14 | 0.48 | 1.23 | 1.01, 1.50 | 0.04 |
| Peripheral artery disease | 1.31 | 1.02, 1.69 | 0.04 | 1.16 | 0.90, 1.50 | 0.25 | 1.21 | 0.93, 1.57 | 0.16 |
| Stroke | 1.26 | 0.92, 1.71 | 0.03 | 1.34 | 0.98, 1.83 | 0.06 | 1.33 | 0.98, 1.79 | 0.07 |
| Depression | 1.96 | 1.33, 2.90 | 0.007 | 137 | 0.92, 2.03 | 0.12 | 1.79 | 1.21, 2.66 | 0.004 |
| Log interleukin-6 | 1.16 | 0.95, 1.42 | 0.15 | 1.30 | 1.06, 1.60 | 0.01 | 0.99 | 0.81, 1.21 | 0.90 |
1
Adjusted for age and sex.
2
Selenium quartiles 1, 2, and 3 were compared with quartile 4 (reference group).
3
P for trend was obtained by considering selenium quartile as an ordinal variable: 0.04, 0.14, and 0.007 for low hip, knee, and grip strengths, respectively.
4
Adjusted for age, sex, education level, BMI, and total energy intake.
5
P for trend was obtained by considering selenium quartile as an ordinal variable: 0.04, 0.01, and 0.08 for low hip, knee, and grip strengths, respectively.