Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Feb 27;4(2):e4627. doi: 10.1371/journal.pone.0004627

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Kandimalla et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

A–D: Uptake of fluorescein labeled Aβ40 (F-Aβ40) and Alexa Fluor® 647 labeled cholera toxin (AF647-CT), caveolae-mediated endocytosis marker, by differentiated PC12 cells following 30 min incubation. (A) F-Aβ40 uptake; (B) Uptake of AF647-CT; (C) Sparse co-localization of F-Aβ40 and AF647-CT as indicated by the white masked areas; (D) Superimposition of images A and B on the differential interference contrast (DIC) image to show the location of the fluorophores in the cells. E–G: Uptake of F-Aβ40 and AF647-CT in differentiated PC12 cells treated with filipin, which is known to inhibit caveolae mediated endocytosis. (E) Uptake of F-Aβ40; (F) Substantial reduction in AF647-CT uptake in the cells treated with filipin; (G). Superimposition of images E and F on the differential interference contrast (DIC) image to show the health of filipin treated cells.