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. 2009 Feb 27;4(2):e4627. doi: 10.1371/journal.pone.0004627

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Kandimalla et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A–D: Uptake of fluorescein labeled Aβ42 (F-Aβ42) and Alexa Fluor® 633 labeled transferrin (AF633-Trf), clathrin-mediated endocytosis marker, by differentiated PC12 cells following 30 min incubation. (A) F-Aβ42 uptake; (B) Uptake of AF633-Trf; (C) Superimposition of images A and B show limited co-localization of F-Aβ42 and AF633-Trf. (D) A magnified portion of image C (enclosed in the white rectangle) to indicate the lack of co-localization of both fluorophores. I–II: Histograms of fluorescence intensity in differentiated PC12 cells treated with (I) F-Aβ42; and (II) AF633-Trf, at 37°C and 4°C.