Table 2. Backward regression models relating change in creatinine clearance over 3-year follow-up and total plasma PUFAs at baseline.

	Dependent change in creatinine clearance
	β (SE)	P
Total plasma PUFAs, mg/L	0.43 (0.11)	<0.0001
Plasma n-3 FA, mg/L	6.28 (1.29)	<0.0001
Plasma linolenic acid, mg/L	0.19 (0.05)	0.0004
Plasma n-6 FA, mg*10/L	3.62 (1.19)	0.03
Plasma linoleic acid, mg*10/L	0.08 (0.03)	0.004
Plasma arachidonic acid, mg*10/L	0.24 (0.06)	<0.0001

Data adjusted for creatinine clearance at baseline, education, cigarette-smoking pack-years, MMSE score, energy intake, alcohol consumption, LDL cholesterol, HDL cholesterol, self-reported cancer, cardiovascular disease, and hypertension. Covariates were selected using a Pearson correlation coefficient <0.10.