Figure 4. PI-103 induces apoptosis of KSHV vGPCR-expressing cells more effectively than rapamycin.

(A) Effect of the treatment with 10 μM LY294002 (LY), 10 nM rapamycin (Rap), 10 μM PI-103, or DMSO (control) on EC-vGPCR apoptosis. Cells were cultured for 6 hours (A) or 24 hours (B) in the presence of the different compounds. Twenty-four hours following initiation of the treatment, cells were harvested and processed for flow cytometry analysis. Results are illustrated as percentage of apoptotic cells and are from a representative independent experiment that was repeated three times with similar results. * p <0.05.