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Multiple points of FTY720 interference with sphingolipid metabolism and signaling. FTY720 is phosphorylated by SphK2, and the formed FTY720-P activates S1P1,3–5 receptors. Also FTY720 can inhibit the cannabinoid receptor 1 (CB1). Intracellularly FTY720 inhibits S1P lyase, cPLA2, and ceramide synthases. Overall FTY720 action favors anti-inflammatory responses. Cer1P, ceramide 1-phosphate.
