TABLE 2.
Shh-regulated expression in primary UGM cells and UGS tissues
|
Gene
|
Gene
expressiona
|
||
|---|---|---|---|
|
Response to Shh
|
Response to cyclopamine
|
||
| Array | Primary UGM | UGS organ culture | |
| Gli1 | ↑ | ↑ | ↓ |
| Ptc1 | ↑ | ↑ | ↓ |
| Igfbp-6 | ↑ | ↑ | ↓ |
| Igfbp-3 | ↑ | ↑ | ↓ |
| Fbn2 | ↑ | ↑ | ↓ |
| Ntrk3 | ↑ | ↑ | ↓ |
| Agpt4 | ↑ | ↑ | ↓ |
| Dner | ↑ | ↑ | 0 |
| Hsd11b1 | ↑ | ↑ | 0 |
| Artn | ↑ | ↑ | 0 |
| Tnmd | ↑ | 0 | ↓ |
| Timp3 | ↑ | 0 | ↓ |
| Tiam1 | ↑ | 0 | ↓ |
| Plxna2 | ↑ | 0 | ↓ |
| BRAK | ↑ | 0 | ↓ |
| Fgf5 | ↑ | 0 | 0 |
| Dmp1 | ↓ | ↓ | ↑ |
| Mmp13 | ↓ | ↓ | ↑ |
| Rgs4 | ↓ | 0 | 0 |
| Sufu | ↓ | 0 | ↑ |
a
Note: gene expression induced by Shh (↑) is expected to be inhibited by cyclopamine (↓). ↑, increased expression; ↓, decreased expression; 0, no significant change. ↑ or ↓ signifies at least 2-fold statistically significant (p < 0.05) change in expression in replicate experiments.