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. 2009 Feb 27;284(9):5630–5636. doi: 10.1074/jbc.M806962200

FIGURE 4.

FIGURE 4.

p38 MAPK contributes to improper Smad2 signaling in mgN/mgN aortas. A, thoracic aortas from P10 wild-type (WT) and Fbn1-null (mgN) mice immunostained for phospho-p38 MAPK. Scale bar, 50 μm. B, representative immunoblots of phospho-ATF2 and phospho-Smad2 in the thoracic aortas of wild-type or Fbn1-null mice (n = 6) treated with the phospho-p38 MAPK inhibitor or placebo. C, representative immunoblots of phospho-p38 MAPK (phospho-p38) and phospho-Smad2 in the thoracic aortas of untreated wild-type or Fbn1-null mice (n = 6) sacrificed at P4 or P10. The bar graphs in B and C summarize experimental (white) and control data (black) normalized against an internal control (β-tubulin or β-actin); wild-type values are arbitrarily expressed as 1 unit. The asterisks indicate values statistically different from those of control samples (Student's t test, p ≤ 0.05).