Table 5.

Description of Articles Comparing Accuracy of PSA and PSA Dynamic

First Author	No. of Patients	End Point and Cohort	Results	Comment
Eggener6	995	Biopsy result in men with initial negative biopsy	Negative predictive value of PSA velocity slightly higher (91% v 88%)than PSA	PSA and PSA velocity used as binary predictors: would different cut points have given different results?
Djavan17	559	Biopsy result	AUC greater for PSA than PSA velocity	Unclear whether AUC for PSA and PSA velocity were calculated on the same patients
Djavan18	273	Biopsy result	AUC greater for PSA than PSA velocity	Unclear whether AUC for PSA and PSA velocity were calculated on the same patients
Sun19	12,078	Cancer diagnosis in men undergoing PSA screening	AUC greater for PSA than PSA velocity	Verification bias: men not undergoing biopsy assumed to be cancer free
Moul20	11,861	Cancer diagnosis in men undergoing PSA screening	AUC greater for PSA than PSA velocity	Verification bias: men not undergoing biopsy assumed to be cancer free
Ciatto21	87	Biopsy result in men with initial negative biopsy	AUC higher for PSA velocity than PSA (0.74 v 0.67)	Only 13 cases; CIs around AUC likely to be wide
Lynn22	158	Biopsy result	AUC greater for PSA than PSA velocity	Short interval between PSA measurements
Ukimura23	110	Biopsy result in men with initial negative biopsy	AUC greater for PSA velocity than PSA (values not given)	Specificity of PSA and PSA velocity similar at high sensitivity
Carter5	980	Long-term prediction of prostate cancer death from archived blood samples	AUC for PSA velocity slightly greater than for PSA (0.75 v 0.74) when PSA values restricted	Only 20 cases; CIs around AUC likely to be wide
Berger24	4,800	Cancer diagnosis in men undergoing PSA screening	AUC much greater for PSA velocity than PSA (0.87 v 0.65)	Verification bias: men not undergoing biopsy assumed to be cancer free; unclear whether AUC for PSA and PSA velocity were calculated on the same patients
Whittemore25	320	Long-term prediction of prostate cancer death from archived blood samples	AUC greater for PSA than change in PSA	All samples within 7 years of diagnosis
Barak26	147	Biopsy result	PSA velocity had slightly lower sensitivity but much higher specificity than PSA	PSA and PSA velocity used as binary predictors: would different cut points have given different results?
Loeb16	6,844	Cancer diagnosis in men undergoing PSA screening	AUC slightly greater for a model that included both PSA velocity and PSA compared with a model that included PSA alone (0.83 v 0.81)	Verification bias: men not undergoing biopsy assumed to be cancer free
Thompson15	5,519	Biopsy in men participating in the Prostate Cancer Prevention Trial	PSA dynamics did not improve prediction	High-quality data from a randomized trial

Abbreviations: PSA, prostate-specific antigen; AUC, area under the curve.