Table 2.

Patients With Ixabepilone-Related Toxicity During Cycle 1 by Dose Level and NCI-CTC Toxicity Grade

Toxicity	No. of Patients With Toxicity at Dose Level
	3 mg/m2/d (n = 3)				4.5 mg/m2/d (n = 3)				6 mg/m2/d (n = 3)				8 mg/m2/d (n = 6)				10 mg/m2/d (n = 3)
	Grade 1	Grade 2	Grade 3	Grade 4	Grade 1	Grade 2	Grade 3	Grade 4	Grade 1	Grade 2	Grade 3	Grade 4	Grade 1	Grade 2	Grade 3	Grade 4	Grade 1	Grade 2	Grade 3	Grade 4
Allergy/immunology
Allergic reaction																		1
Blood/bone marrow
Hemoglobin		1	1			1				2			2	1	2				2
Neutrophils							2		1		1				4	1*				3
Platelets									1		1		1		1*		3
Cardiovascular
Hypertension													1				1
Constitutional
Fatigue		1											3					1	1
Fever without neutropenia					1												1
Dermatology
Alopecia					1								3	2
Flushing																	1
Pruritus																	1
GI
Anorexia	1								1						1*		2
Constipation										1								1
Dehydration														1	1*
Diarrhea																	1
Nausea							1				1		1	1	1*		2
Stomatitis															1*		1
Vomiting						1					1		2		1		2
Hemorrhage
Epistaxis													1
Hepatic
Increased alkaline phosphatase													1					1
Increased bilirubin									1				1	1
Hypoalbuminemia																	1
Increased AST					1				1	1			3				1
Increased ALT									1				2
Infection
Fever/neutropenia															1*
Metabolic/laboratory
Hyperkalemia													1
Hypertriglyceridemia													1
Neurology
Dizziness															1*
Irritability (≤ 3 years)														1
Sensory neuropathy					1				1				1		1*		1
Pain
Abdominal													1				2
Bone
Myalgia	1														1*			1
Other													1

Abbreviation: NCI-CTC, National Cancer Institute Common Toxicity Criteria.

^*Toxicities occurring in the same patient.