Table 3.
Pharmacokinetic Parameters for Ixabepilone From 16 Children and Adolescents
| Patient | Dose Level (mg/m2/d) | Dose (mg) | AUC0-∞ (ng·h/mL) | Clearance (mL/min/m2) | Vdss (L/kg) | Half-Life (h) |
|---|---|---|---|---|---|---|
| 1 | 3.0 | 2.3 | 182 | 272 | 13.3 | 20.2 |
| 2 | 3.0 | 2.4 | 262 | 188 | 5.3 | 10.1 |
| 3 | 3.0 | 6.6 | 210 | 238 | 6.0 | 15.8 |
| 4 | 4.5 | 4.4 | 89.1 | 848 | 6.5 | 4.7 |
| 5 | 4.5 | 7.1 | 261 | 291 | 7.8 | 14.9 |
| 6 | 4.5 | 7.0 | 285 | 264 | 15.1 | 30.8 |
| 7 | 4.5 | 3.2 | 151 | 506 | 22.8 | 18.0 |
| 8 | 6.0 | 6.3 | 272 | 364 | 9.0 | 12.4 |
| 9 | 6.0 | 4.2 | 100 | 998 | 18.8 | 8.4 |
| 10 | 6.0 | 10.0 | 133 | 737 | 7.4 | 7.5 |
| 11 | 8.0 | 4.0 | 362 | 368 | 17.3 | 15.7 |
| 12 | 8.0 | 14.0 | 326 | 403 | 10.3 | 17.2 |
| 17 | 8.0 | 18.0 | 476 | 281 | 12.6 | 13.8 |
| 18 | 8.0 | 9.4 | 216 | 616 | 18.3 | 13.9 |
| 19 | 8.0 | 10.4 | 293 | 451 | 8.1 | 8.3 |
| 14 | 10.0 | 11.9 | 223 | 767 | 17.0 | 12.2 |
Abbreviations: AUC0-∞, area under the plasma concentration-time curve from time 0 to infinity; Vdss, volume of distribution at steady-state.