Table 4.
Comparison of Pharmacokinetic Parameters in Children and Adults11 Receiving Ixabepilone on the Daily for 5 Days Schedule
| Pharmacokinetic Parameter | Adults (n = 22) | Children (n = 16) |
|---|---|---|
| AUC0-∞ at 6 mg/m2/d, ng·h/mL | ||
| Mean | 272 | 168 |
| SD | 72 | 91 |
| No. of patients | 14 | 3 |
| AUC0-∞ at 8 mg/m2/d, ng·h/mL | ||
| Mean | 338 | 335 |
| SD | 108 | 96 |
| No. of patients | 8 | 5 |
| Clearance, mL/min/m2 | ||
| Mean | 402 | 475 |
| SD | 125 | 247 |
| Vdss, L/kg | ||
| Mean | 11.8 | 12.2 |
| SD | 6.3 | 5.4 |
| Half-life, h | ||
| Mean | 16.8 | 14.0 |
| SD | 6.0 | 6.1 |
Abbreviations: AUC0-∞, area under the plasma concentration-time curve from time 0 to infinity; SD, standard deviation; Vdss, volume of distribution at steady-state.