Table 3. Genotype and allele frequencies of SNPs PD-1.3, PD-1.5, and PD-1.6 in VKH patients and healthy controls.
| PDCD1 SNPs | VKH patients (%) | Healthy controls (%) | χ2 | p | pc | Odds ratio (95%CI) |
|---|---|---|---|---|---|---|
|
PD-1.3 |
||||||
| Genotype |
||||||
| GG |
247 (100) |
289 (100) |
— |
— |
— |
— |
| AG |
— |
— |
||||
| AA |
— |
— |
||||
| Allele |
||||||
| G |
494 (100) |
578 (100) |
— |
— |
— |
— |
| A |
— |
— |
||||
|
PD-1.5 |
||||||
| Genotype |
||||||
| CC |
131 (53.0) |
176 (60.9) |
6.786 |
0.034 |
0.306 |
— |
| CT |
91 (36.8) |
99 (34.3) |
||||
| TT |
25 (10.1) |
14 (4.8) |
||||
| Allele |
||||||
| C |
353 (71.5) |
451 (78.0) |
6.132 |
0.013 |
0.078 |
0.705 (0.534–0.930) |
| T |
141 (28.5) |
127 (22.0) |
||||
|
PD-1.6 |
||||||
| Genotype |
||||||
| AA |
124 (50.2) |
136 (47.1) |
5.171 |
0.075 |
— |
— |
| AG |
108 (43.7) |
119 (41.2) |
||||
| GG |
15 (6.1) |
34 (11.7) |
||||
| Allele |
||||||
| A |
356 (72.1) |
391 (67.6) |
2.413 |
0.12 |
— |
1.232 (0.947–1.603) |
| G | 138 (27.9) | 187 (32.4) |
The distribution of genotype frequencies of each SNP in the healthy controls did not show significant deviation from the Hardy-Weinberg equilibrium. The frequency of the C allele and CC genotype of PD-1.5 were lower in VKH patients than in healthy controls, but the differences were not statistically significant following the Bonferroni correction. The genotype and allele frequencies of PD-1.3 and PD-1.6 in VKH patients were not different from those in healthy controls. Only the GG genotype and the G allele of PD-1.3 were identified in all patients and controls