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. 2007 Feb 28;13:293–308.

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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Biological pathway for the differentially expressed neuronal cell death genes in serum-deprived retinal ganglion cells. Pathways were identified by incorporating the microarray results (genes which are differentially expressed at 24, 48, and 96 h) into the Pathway Assit software. The pathway was constructed on this software by searching for the shortest path to connect the genes of interest by other genes or cell processes with which they interacted through expression or regulation only. Three major biologic processes are identified (apoptosis, death, and DNA fragmentation) and are represented by yellow rectangles. Blue ovals denote genes identified as neuronal cell death, and red ovals new genes connected to this pathway.