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. Author manuscript; available in PMC: 2009 Dec 3.
Published in final edited form as: Biochemistry. 2008 Dec 2;47(48):12680–12688. doi: 10.1021/bi801427c

Figure 2.

Figure 2

Liposome leakage induced by hIAPP1-19 (blue diamonds) and the rIAPP1-19 fragment (green diamonds) at pH 7.5. The peptide-to-lipid ratio was varied by adding 250 nM (A), 1 μM (B), and 5 μM (C) solutions of either rIAPP1-19 or hIAPP1-19 to POPG liposomes containing carboxyfluorescein (1.5 μM) and enough empty POPG liposomes (not containing carboxyfluorescein) to create the indicated molar ratio of peptide to lipid. The fluorescence signal was recorded at 100 seconds after peptide injection and normalized to the total possible signal upon addition of detergent.