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Inactivation of purified human alkyltransferase in vitro
| Alkyltransferase Tested | Inhibitor | ED50 (μM)* | |
|---|---|---|---|
| No DNA | + DNA | ||
| Wild type | BG | 0.30 | 0.10 |
| Wild type | 2 | 0.017 | 0.004 |
| Wild type | 1 | 0.23 | 0.053 |
| Wild type | 3 | 80 | 45 |
| Wild type | 5 | 0.25 | 0.16 |
| Wild type | 4 | 0.32 | 0.20 |
| Wild type | 6 | 185 | 90 |
| Wild type | 7 | >1000 | >1000 |
| S159A mutant | 2 | 0.013 | 0.003 |
| S159A mutant | 1 | 0.16 | 0.028 |
Results shown are the mean values for 3–5 assays with different preparations of recombinant alkyltransferase, which agreed within ±20%.
