Table 2.
Frequency distribution of DNMT3b–149C>T and DNMT3b–579G>T genotypes and their associations with risk of SCCHN
| DNMT3b Genotype | No of cases (%) | No of controls (%)a | Pb | Adjusted OR (95% CI)c | Pc |
|---|---|---|---|---|---|
| All subjects | 832 (100.0) | 843 (100.0) | |||
| DNMT3b -149C>T | |||||
| CC | 259 (31.1) | 266 (31.6) | 0.011 | referent | |
| CT | 384 (46.2) | 433 (51.4) | 0.91 (0.72-1.14) | 0.409 | |
| TT | 189 (22.7) | 144 (17.1) | 1.35 (1.01-1.80) | 0.043 | |
| C-allele carriers | 643 (77.3) | 699 (82.9) | referent | ||
| TT | 189 (22.7) | 144 (17.1) | 0.004 | 1.43 (1.11-1.84) | 0.006 |
| DNMT3b -579 G>T | |||||
| GG | 299 (35.9) | 305 (36.2) | 0.341 | referent | |
| GT | 376 (45.2) | 401 (47.6) | 0.90 (0.72-1.13) | 0.368 | |
| TT | 157 (18.9) | 137 (16.2) | 1.14 (0.85-1.53) | 0.380 | |
| G-allele carriers | 675 (81.1) | 706 (83.7) | 0.159 | referent | |
| TT | 157 (18.9) | 137 (16.3) | 1.21 (0.93-1.57) | 0.163 |
a
The observed genotype frequency among the control subjects was in agreement with the Hardy-Weinberg equilibrium (p2+2pq+q2=1) (χ2 =2.045, P=0.153 for DNMT3B –149C> T and χ2 =0.073, P=0.787 for DNMT3B -579G>T).
b
Two-sided χ2 test for either genotype distribution or allele frequency.
c
Adjusted for age, sex, smoking status, and alcohol use in a logistic regression model.