Table 3.
Frequency distribution of combined DNMT3b–149C>T and DNMT3b–579G>T genotypes and the association with SCCHN risk
| DNMT3b genotype carriers | No of cases (%) | No of controls (%) | Pa | Adjusted OR (95% CI)b | Pb |
|---|---|---|---|---|---|
| Total | 832 | 843 | |||
| -149C/-579G | 623 (74.9) | 675 (80.1) | 0.019 | referent | |
| -149TT/-579G | 20 (2.4) | 24 (2.8) | 0.94 (0.50-1.76) | 0.845 | |
| -149C/-579TT | 52 (6.2) | 31 (3.7) | 1.81 (1.13-2.91) | 0.014 | |
| -149TT/-579TT | 137 (16.5) | 113 (13.4) | 1.32 (0.99-1.75) | 0.058 | |
| -149C/-579G | 623 (74.9) | 675 (80.1) | 0.037 | referent | |
| -149TT/-579G+-149C/579TT | 72 (8.7) | 55 (6.5) | 1.44 (0.98-2.11) | 0.063 | |
| -149TT/-579TT | 137 (16.4) | 113 (13.4) | 1.32 (0.99-1.75) | 0.058 | |
| Ptrend =0.025 | |||||
| -149C/-579G | 623 (74.9) | 675 (80.1) | 0.011 | referent | |
| -149TT or -579TT | 209 (25.1) | 168 (19.9) | 1.36 (1.07-1.73) | 0.013 |
a
Two-sided χ2 test for either genotype distribution or allele frequency.
b
Adjusted for age, sex, smoking status, and alcohol use in a logistic regression model.