Table 4.
Stratification analysis of SCCHN risk associated with the DNMT3b–149C>T and DNMT3b–579G>T combined genotypes
| Variables | No of cases (%) |
No of controls (%) |
Adjusted OR (95% CI)a |
P | |||
|---|---|---|---|---|---|---|---|
| -149C/-579G | -149TT or -579TT | -149C/-579G | -149TT or -579TT | -149C/-579G | -149TT or -579TT | ||
| Age (years) | |||||||
| ≤ 57 | 329 (74.1) | 115 (25.9) | 362 (80.6) | 87 (19.4) | referent | 1.42 (1.02-1.97) | 0.037 |
| > 57 | 294 (75.8) | 94 (24.2) | 313 (79.4) | 81 (20.6) | referent | 1.31 (0.91-1.89) | 0.145 |
| Sex | referent | ||||||
| Female | 154 (75.5) | 50 (24.5) | 160 (82.0) | 35 (18.0) | referent | 1.41 (0.84-2.37) | 0.190 |
| Male | 469 (74.7) | 159 (25.3) | 515 (79.5) | 133 (20.5) | referent | 1.33 (1.01-1.75) | 0.040 |
| Smoking status | referent | ||||||
| Never | 165 (76.7) | 50 (23.3) | 318 (79.9) | 80 (20.1) | referent | 1.24 (0.83-1.85) | 0.305 |
| Former | 253 (77.1) | 75 (22.9) | 246 (79.1) | 65 (20.9) | referent | 1.18 (0.81-1.72) | 0.401 |
| Current | 205 (70.9) | 84 (29.1) | 111 (82.8) | 23 (17.2) | referent | 2.04 (1.19-3.50) | 0.010 |
| Drinking status | referent | ||||||
| Never | 141 (72.3) | 54 (27.7) | 266 (77.8) | 76 (22.2) | referent | 1.36 (0.90-2.05) | 0.143 |
| Former | 166 (77.9) | 47 (22.1) | 128 (78.1) | 36 (21.9) | referent | 0.97 (0.59-1.61) | 0.916 |
| Current | 316 (74.5) | 108 (25.5) | 281 (83.4) | 56 (16.6) | referent | 1.59 (1.09-2.32) | 0.016 |
| Tumor site | referent | ||||||
| Oral cavity | 189 (75.6) | 61 (24.4) | 675 (80.1) | 168 (19.9) | referent | 1.37 (0.95-1.96) | 0.089 |
| Pharynx | 322 (74.9) | 108 (25.1) | 675 (80.1) | 168 (19.9) | referent | 1.34 (1.01-1.78) | 0.046 |
| Larynx | 112 (73.7) | 40 (26.3) | 675 (80.1) | 168 (19.9) | referent | 1.58 (1.02-2.46) | 0.040 |
a
Adjusted for age, sex, smoking status, and alcohol use in a logistic regression model, where it was appropriate.