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. Author manuscript; available in PMC: 2009 Nov 21.
Published in final edited form as: ACS Chem Biol. 2008 Nov 21;3(11):703–710. doi: 10.1021/cb800185h

Figure 4. The effect of heme flattening on the N-terminal domain.

Figure 4

Shown is a comparison of P115A molecule D (silver) and wild-type monoclinic Tt H-NOX molecule A (gold) heme/N-terminal interface. The planar heme makes new contacts with Met1 and Ile5 of α helix A, which shifts the helix away from the C-terminal domain. Shifting of α helix A, along with the rest of the N-terminal region causes shifts over 4.9 Å.