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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Chem Res Toxicol. 2009 Jan;22(1):118–128. doi: 10.1021/tx800253x

Figure 1.

Figure 1

Change in glomerular filtration rates (GFR) in the different treatment groups (all GFR values corrected for animal body weight and presented as means + standard deviations (n=6/group)), differences between groups was significant at p<0.001 (one-way ANOVA) *significant compared to untreated controls using a post-hoc pairwise multiple comparison (Holm-Sidak method).

Groups: con: vehicle-treated controls, CsA10: 10 mg/kg/day cyclosporine, CsA25: 25 mg/kg/day cyclosporine, Rapa1: 1 mg/kg/day sirolimus, CsA10/Rapa1: co-administration of 10 mg/ kg/ day cyclosporine and 1 mg/kg/day sirolimus, CsA25/Rapa1: co-administration of 25 mg/kg/day cyclosporine and 1 mg/kg/day sirolimus.