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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Chem Res Toxicol. 2009 Jan;22(1):118–128. doi: 10.1021/tx800253x

Figure 7.

Figure 7

Changes in urine metabolite patterns after 28 days of treatment as assessed by 1H-NMR spectroscopy (all urine metabolites determined semi-quantitatively by 1H-NMR, all values were normalized based on the total integral and are presented as means + standard deviations (n=6 for all groups), group comparison by one-way ANOVA, *significance levels estimated using a post-hoc pairwise multiple comparison (Holm-Sidak method).

Groups: con: vehicle-treated controls, CsA10: 10 mg/kg/day cyclosporine, CsA25: 25 mg/kg/day cyclosporine, Rapa1: 1 mg/kg/day sirolimus, CsA10/Rapa1: co-administration of 10 mg/ kg/ day cyclosporine and 1 mg/kg/day sirolimus, CsA25/Rapa1: co-administration of 25 mg/kg/day cyclosporine and 1 mg/kg/day sirolimus.