Changes in urine metabolite patterns after 28 days of treatment as assessed by 1H-NMR spectroscopy (all urine metabolites determined semi-quantitatively by 1H-NMR, all values were normalized based on the total integral and are presented as means + standard deviations (n=6 for all groups), group comparison by one-way ANOVA, *significance levels estimated using a post-hoc pairwise multiple comparison (Holm-Sidak method).
Groups: con: vehicle-treated controls, CsA10: 10 mg/kg/day cyclosporine, CsA25: 25 mg/kg/day cyclosporine, Rapa1: 1 mg/kg/day sirolimus, CsA10/Rapa1: co-administration of 10 mg/ kg/ day cyclosporine and 1 mg/kg/day sirolimus, CsA25/Rapa1: co-administration of 25 mg/kg/day cyclosporine and 1 mg/kg/day sirolimus.