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. 2009 Mar;58(3):543–549. doi: 10.2337/db08-0981

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Copyright © 2009, American Diabetes Association

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FIG. 2. — Rate sensitivity and glucose sensitivity of the β-cells during OGTT. A: Rate sensitivity is the insulin secretion response to the pace of increase in plasma glucose. Control subjects, □. Patients with m.3243A>G mutation: , group 1; , group 2; and ▪, group 3. The apparently high rate sensitivity in group 1 is partly due to the higher insulin sensitivity in the control subjects, because rate sensitivity tends to be inversely correlated with insulin sensitivity (see Table 2 for respective disposition index). B: Glucose sensitivity is the insulin dose-response function to absolute glucose level during OGTT.

Inline graphic — Rate sensitivity and glucose sensitivity of the β-cells during OGTT. A: Rate sensitivity is the insulin secretion response to the pace of increase in plasma glucose. Control subjects, □. Patients with m.3243A>G mutation: , group 1; , group 2; and ▪, group 3. The apparently high rate sensitivity in group 1 is partly due to the higher insulin sensitivity in the control subjects, because rate sensitivity tends to be inversely correlated with insulin sensitivity (see Table 2 for respective disposition index). B: Glucose sensitivity is the insulin dose-response function to absolute glucose level during OGTT.