TABLE 3.

Univariate correlations between progranulin mRNA expression in visceral and subcutaneous adipose tissue and measures of obesity, insulin sensitivity, and parameters of inflammation (n = 55)

	r	P value	Adjusted for BMI
			r	P value
Visceral progranulin mRNA
Serum progranulin	0.27	<0.01	0.17	0.03
CRP	0.25	<0.01	0.18	0.02
MCP-1	0.18	0.03	0.06	0.6
Visceral fat area	0.46	<0.001	0.28	<0.01
BMI	0.41	<0.01	—	—
Body fat (%)	0.39	<0.01	0.04	0.7
Visceral macrophage number	0.62	<0.001	0.45	<0.001
HDL cholesterol	−0.35	<0.001	−0.12	0.1
GIR	−0.31	<0.01	−0.11	0.1
Subcutaneous progranulin mRNA
Subcutaneous macrophage number	0.6	<0.001	0.38	<0.001
CRP	0.34	<0.001	0.22	0.01

GIR, glucose infusion rate during the steady state of a euglycemic-hyperinsulinemic clamp.