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. 2009 Mar;58(3):718–725. doi: 10.2337/db08-1098

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Copyright © 2009, American Diabetes Association

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.

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FIG. 3. — Hypoxia and AT inflammation. AT pO₂ was inversely correlated with the inflammation markers CD68 mRNA (A) and MAC 2/CD163 mRNA (B), with the chemokine MIP1α mRNA expression (C) and MIP1α secretion into culture media ex vivo (D). Previous studies in our lab demonstrated a strong correlation between MAC2/CD163 and CD68 mRNA and macrophage infiltration by macrophage staining in AT sections by immunohistochemistry (R² = 0.77, P < 0.001) (B. Kozak, J. Gimble, S.R. Smith, unpublished data). Males are represented by squares and females by circles, filled with different colors as follows: white for lean, gray for O/O without type 2 diabetes, and black for O/O with type 2 diabetes.