TABLE 3.
Mean circulating resistin levels per genotype at SNPs in or near RETN in the Framingham Offspring Study*
| SNP identification | Total N | MAF (allele) | M/M
|
M/m
|
m/m
|
Nominal P† | Pe† | Nominal P (BMI adjusted)‡ | Pe (BMI adjusted)‡ | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Means ± SD | n | Means ± SD | n | Mean ± SD | |||||||
| rs794070 | 1,834 | 0.21 (C) | 1,143 | 14.02 ± 6.59 | 612 | 14.91 ± 8.79 | 79 | 16.03 ± 9.96 | 0.003 | 0.051 | 0.004 | 0.07 |
| rs11883223 | 1,852 | 0.17 (A) | 1,294 | 14.36 ± 7.46 | 508 | 14.39 ± 7.33 | 50 | 14.41 ± 6.23 | 0.63 | 1.0 | 0.49 | 1.0 |
| rs2081075 | 1,833 | 0.29 (A) | 910 | 14.22 ± 7.79 | 765 | 14.35 ± 7.16 | 158 | 15.50 ± 6.93 | 0.02 | 0.31 | 0.03 | 0.36 |
| rs10418380 | 1,773 | 0.32 (G) | 830 | 14.26 ± 7.26 | 748 | 14.38 ± 7.39 | 195 | 14.19 ± 5.50 | 0.63 | 1.0 | 0.44 | 1.0 |
| rs10413807 | 1,852 | 0.21 (C) | 1,151 | 14.32 ± 6.63 | 622 | 14.33 ± 8.11 | 79 | 13.66 ± 5.17 | 0.33 | 1.0 | 0.52 | 1.0 |
| rs12460483 | 1,875 | 0.12 (A) | 1,446 | 14.23 ± 7.61 | 407 | 14.94 ± 7.32 | 22 | 14.15 ± 4.69 | 0.01 | 0.20 | 0.01 | 0.20 |
| rs12459044 | 1,852 | 0.14 (G) | 1,365 | 14.21 ± 7.61 | 468 | 14.96 ± 7.42 | 19 | 14.60 ± 5.58 | 0.004 | 0.07 | 0.003 | 0.051 |
| rs7408174 | 1,827 | 0.31 (C) | 901 | 14.32 ± 7.64 | 759 | 14.26 ± 6.88 | 167 | 14.40 ± 6.33 | 0.48 | 1.0 | 0.62 | 1.0 |
| rs1862513 | 1,876 | 0.29 (C) | 937 | 13.98 ± 6.47 | 786 | 14.86 ± 8.82 | 153 | 14.43 ± 5.90 | 0.05 | 0.57 | 0.07 | 0.66 |
| rs3219177 | 1,866 | 0.21 (T) | 1,141 | 14.31 ± 7.56 | 650 | 14.63 ± 7.75 | 75 | 13.85 ± 4.78 | 0.20 | 0.96 | 0.27 | 0.99 |
| rs3745367 | 1,867 | 0.24 (A) | 1,058 | 14.23 ± 7.28 | 700 | 14.71 ± 8.19 | 109 | 14.01 ± 5.07 | 0.15 | 0.90 | 0.22 | 0.97 |
| rs3219178 | 1,826 | 0.42 (G) | 603 | 14.67 ± 8.00 | 896 | 14.26 ± 7.48 | 327 | 13.96 ± 5.76 | 0.27 | 0.99 | 0.40 | 1.0 |
| rs10402265 | 1,858 | 0.14 (G) | 1,369 | 14.33 ± 7.35 | 451 | 14.61 ± 7.70 | 38 | 13.13 ± 4.17 | 0.76 | 1.0 | 0.71 | 1.0 |
| rs3745369 | 1,861 | 0.50 (C) | 456 | 13.67 ± 6.45 | 937 | 14.45 ± 7.73 | 468 | 15.01 ± 8.05 | 0.003 | 0.056 | 0.004 | 0.07 |
| rs1477341 | 1,867 | 0.44 (T) | 581 | 13.66 ± 7.16 | 908 | 14.48 ± 7.06 | 378 | 15.22 ± 8.34 | 9.4 × 10−6 | 0.0005 | 7.3 × 10−6 | 0.0005 |
| rs4804765 | 1,836 | 0.33 (T) | 831 | 14.03 ± 7.49 | 806 | 14.47 ± 6.90 | 199 | 15.26 ± 9.16 | 0.0010 | 0.02 | 0.0005 | 0.009 |
| rs1423096 | 1,858 | 0.09 (A) | 1,496 | 14.16 ± 7.50 | 338 | 15.12 ± 6.65 | 24 | 16.50 ± 9.90 | 0.0007 | 0.01 | 0.0015 | 0.03 |
| rs10401670 | 1,852 | 0.43 (T) | 596 | 13.91 ± 7.79 | 909 | 14.37 ± 6.97 | 347 | 15.19 ± 8.40 | 0.0001 | 0.004 | 5.1 × 10−5 | 0.002 |
| rs11882592 | 1,843 | 0.18 (A) | 1,273 | 14.39 ± 7.51 | 529 | 14.25 ± 6.87 | 41 | 16.66 ± 14.03 | 0.71 | 1.0 | 0.67 | 1.0 |
| rs10411016 | 1,843 | 0.49 (G) | 475 | 14.64 ± 8.53 | 929 | 14.16 ± 6.56 | 439 | 14.48 ± 7.73 | 0.76 | 1.0 | 0.86 | 1.0 |
*
Resistin levels in ng/dl.
†
Adjustment for sex, age, and age2.
‡
Adjustment for sex, age, age2, and BMI. M, major allele; m, minor allele.