TABLE 2.
Genotype distributions, minor allele frequencies, and ORs for rs17782313, rs17700633, rs12970134, rs502933, and rs4450508 near MC4R among 14,940 individuals stratified according to genotype and BMI subgroup or sex-specific waist circumference subgroup
| n (men/women) | Genotype | Minor allele frequency | Additive model OR | P | |||
|---|---|---|---|---|---|---|---|
| rs17782313 | T/T | T/C | C/C | ||||
| BMI | |||||||
| <25 kg/m2 | 4,721 (1,946/2,775) | 2,721 (57) | 1,722 (37) | 278 (6) | 24.1 (23.3–25.0) | ||
| ≥25 kg/m2 | 10,219 (5,887/4,332) | 5,651 (56) | 3,915 (38) | 653 (6) | 25.5 (24.9–26.1) | 1.09 (1.02–1.15) | 0.006* |
| ≥30 kg/m2 | 3,913 (1,988/1,925) | 2,136 (55) | 1,507 (38) | 270 (7) | 26.2 (25.2–27.1) | 1.12 (1.04–1.20) | 0.003* |
| ≥40 kg/m2 | 283 (89/194) | 148 (52) | 112 (40) | 23 (8) | 27.9 (24.3–31.8) | 1.20 (0.99–1.45) | 0.06 |
| Waist | |||||||
| <80 (women) or <94 cm (men) | 5,374 (2,834/2,540) | 3,107 (58) | 1,954 (36) | 313 (6) | 24.0 (23.2–24.8) | ||
| ≥80 (women) or ≥94 cm (men) | 9,546 (4,986/4,560) | 5,247 (55) | 3,681 (38) | 618 (7) | 25.8 (25.1–26.4) | 1.10 (1.03–1.16) | 0.002* |
| ≥88 (women) or ≥102 cm (men) | 5,748 (2,720/3,028) | 3,158 (55) | 2,213 (38) | 377 (7) | 25.8 (25.0–26.6) | 1.09 (1.02–1.16) | 0.009* |
| rs17700633 | G/G | G/A | A/A | ||||
| BMI | |||||||
| <25 kg/m2 | 4,697 (1,939/2,758) | 2,296 (49) | 2,002 (42) | 399 (9) | 29.8 (28.9–30.7) | ||
| ≥25 kg/m2 | 10,135 (5,842/4,293) | 4,685 (46) | 4,427 (44) | 1,023 (10) | 31.9 (31.3–32.6) | 1.12 (1.06–1.18) | 8 × 10−5* |
| ≥30 kg/m2 | 3,871 (1,964/1,907) | 1,744 (45) | 1,707 (44) | 420 (11) | 32.9 (31.9–34.0) | 1.16 (1.08–1.24) | 2 × 10−5* |
| ≥40 kg/m2 | 278 (87/191) | 108 (39) | 143 (51) | 27 (10) | 35.4 (31.5–39.6) | 1.30 (1.08–1.56) | 0.005* |
| Waist | |||||||
| <80 (women) or <94 cm (men) | 5,346 (2,824/2,522) | 2,575 (48) | 2,319 (43) | 452 (9) | 30.1 (29.3–31.0) | ||
| ≥80 (women) or ≥94 cm (men) | 9,467 (4,945/4,522) | 4,394 (47) | 4,104 (43) | 969 (10) | 31.9 (31.2–32.6) | 1.09 (1.03–1.15) | 0.002* |
| ≥88 (women) or ≥102 cm (men) | 5,684 (2,694/2,990) | 2,598 (46) | 2,495 (44) | 591 (10) | 32.3 (31.5–33.2) | 1.10 (1.04–1.17) | 0.001* |
| rs12970134 | G/G | G/A | A/A | ||||
| BMI | |||||||
| <25 kg/m2 | 4,694 (1,934/2,760) | 2,511 (54) | 1,848 (39) | 335 (7) | 26.8 (25.9–27.7) | ||
| ≥25 kg/m2 | 10,174 (5,869/4,305) | 5,073 (50) | 4,276 (42) | 825 (8) | 29.1 (28.5–29.8) | 1.13 (1.07–1.20) | 2 × 10−5* |
| ≥30 kg/m2 | 3,886 (1,979/1,907) | 1,922 (49) | 1,631 (42) | 333 (9) | 29.6 (28.5–30.6) | 1.15 (1.08–1.23) | 6 × 10−5* |
| ≥40 kg/m2 | 282 (88/194) | 130 (46) | 126 (45) | 26 (9) | 31.6 (27.7–35.6) | 1.25 (1.04–1.50) | 0.02* |
| Waist | |||||||
| <80 (women) or <94 cm (men) | 5,333 (2,814/2,519) | 2,843 (53) | 2,104 (40) | 386 (7) | 27.0 (26.1–27.8) | ||
| ≥80 (women) or ≥94 cm (men) | 9,515 (4,976/4,539) | 4,726 (50) | 4,016 (42) | 773 (8) | 29.2 (28.6–29.9) | 1.12 (1.06–1.19) | 3 × 10−5* |
| ≥88 (women) or ≥102 cm (men) | 5,710 (2,715/2,995) | 2,831 (50) | 2,412 (42) | 467 (8) | 29.3 (28.5–30.1) | 1.12 (1.05–1.19) | 4 × 10−4* |
| rs502933 | C/C | C/A | A/A | ||||
| BMI | |||||||
| <25 kg/m2 | 4,637 (1,904/2,733) | 2,002 (43) | 2,067 (45) | 568 (12) | 34.5 (33.6–35.5) | ||
| ≥25 kg/m2 | 10,075 (5,801/4,274) | 4,116 (41) | 4,678 (46) | 1,281 (13) | 35.9 (35.3–36.6) | 1.07 (1.02–1.13) | 0.01 |
| ≥30 kg/m2 | 3,851 (1,963/1,888) | 1,562 (41) | 1,786 (46) | 503 (13) | 36.3 (35.2–37.3) | 1.08 (1.02–1.16) | 0.01 |
| ≥40 kg/m2 | 281 (91/190) | 104 (37) | 136 (48) | 41 (15) | 38.8 (34.7–43.0) | 1.20 (1.01–1.43) | 0.04 |
| Waist | |||||||
| <80 (women) or <94 cm (men) | 5,275 (2,783/2,492) | 2,284 (43) | 2,346 (45) | 645 (12) | 34.5 (33.6–35.4) | ||
| ≥80 (women) or ≥94 cm (men) | 9,418 (4,909/4,509) | 3,824 (41) | 4,393 (47) | 1,201 (13) | 36.1 (35.4–36.8) | 1.08 (1.02–1.13) | 0.006* |
| ≥88 (women) or ≥102 cm (men) | 5,662 (2,688/2,974) | 2,281 (40) | 2,666 (47) | 715 (13) | 36.2 (35.3–37.1) | 1.07 (1.01–1.13) | 0.02 |
| rs4450508 | G/G | G/A | A/A | ||||
| BMI | |||||||
| < 25 kg/m2 | 4,644 (1,916/2,728) | 1,912 (41) | 2,100 (45) | 632 (14) | 36.2 (35.2–37.2) | ||
| ≥25 kg/m2 | 10,145 (5,855/4,290) | 3,988 (39) | 4,781 (47) | 1,376 (14) | 37.1 (36.5–37.8) | 1.05 (0.99–1.10) | 0.08 |
| ≥30 kg/m2 | 3,873 (1,971/1,902) | 1,510 (39) | 1,820 (47) | 543 (14) | 37.5 (36.4–38.6) | 1.06 (1.00–1.13) | 0.06 |
| ≥40 kg/m2 | 282 (86/196) | 100 (36) | 140 (49) | 42 (15) | 39.7 (35.7–43.9) | 1.16 (0.98–1.38) | 0.09 |
| Waist | |||||||
| <80 (women) or <94 cm (men) | 5,293 (2,798/2,495) | 2,192 (41) | 2,391 (45) | 710 (13) | 36.0 (35.1–36.9) | ||
| ≥80 (women) or ≥94 cm (men) | 9,477 (4,961/4,516) | 3,700 (39) | 4,484 (47) | 1,239 (14) | 37.3 (36.6–38.0) | 1.06 (1.01–1.12) | 0.03 |
| ≥88 (women) or ≥102 cm (men) | 5,692 (2,701/2,991) | 2,209 (39) | 2,709 (47) | 774 (14) | 37.4 (36.5–38.3) | 1.05 (1.00–1.12) | 0.07 |
Data are n (%), minor allele frequency (95% CI), and OR (95% CI). Differences in genotype distribution between BMI classifications or waist circumference classifications were calculated applying an additive logistic regression model adjusted for sex and age.
*
P values remained significant after Benjamini-Hochberg correction.