TABLE 3.

Genotype distributions, minor allele frequencies, and ORs for rs17782313, rs17700633, rs12970134, rs502933, and rs4450508 near MC4R among 8,821 individuals with normal glucose tolerance and patients with type 2 diabetes

	n (men/women)	Genotype			Minor allele frequency (95% CI)	Additive model [OR (95% CI)]*	P	Additive model [OR (95% CI)]†	P
rs17782313		T/T	T/C	C/C
Normal glucose tolerance	4,918 (2,276/2,642)	2,802 (57)	1,810 (37)	306 (6)	24.6 (23.8–25.5)
Type 2 diabetes	3,903 (2,317/1,586)	2,135 (55)	1,500 (38)	268 (7)	26.1 (25.1–27.1)	1.08 (0.99–1.18)	0.08	1.04 (0.94–1.14)	0.48
rs17700633		G/G	G/A	A/A
Normal glucose tolerance	4,911 (2,283/2,628)	2,349 (48)	2,114 (43)	448 (9)	30.6 (29.7–31.6)
Type 2 diabetes	3,881 (2,305/1,576)	1,841 (47)	1,658 (43)	382 (10)	31.2 (30.2–32.2)	1.05 (0.97–1.14)	0.26	1.00 (0.91–1.09)	0.96
rs12970134		G/G	G/A	A/A
Normal glucose tolerance	4,882 (2,261/2,621)	2,544 (52)	1,945 (40)	393 (8)	28.0 (27.1–28.9)
Type 2 diabetes	3,839 (2,310/1,580)	1,942 (50)	1,631 (42)	320 (8)	29.2 (28.2–30.2)	1.08 (1.00–1.18)	0.06	1.03 (0.93–1.13)	0.57
rs502933		C/C	C/A	A/A
Normal glucose tolerance	4,843 (2,244/2,599)	2,041 (42)	2,165 (45)	657 (13)	35.5 (34.6–36.5)
Type 2 diabetes	3,834 (2,270/1,561)	1,518 (40)	1,822 (47)	494 (13)	36.6 (35.6–37.7)	1.07 (0.98–1.16)	0.11	1.04 (0.95–1.14)	0.34
rs4450508		G/G	G/A	A/A
Normal glucose tolerance	4,845 (2,253/2,592)	1,975 (41)	2,183 (45)	687 (14)	36.7 (35.7–37.7)
Type 2 diabetes	3,860 (2,289/1,568)	1,460 (38)	1,857 (48)	543 (14)	38.1 (37.0–39.2)	1.07 (0.99–1.16)	0.08	1.07 (0.98–1.16)	0.16

Data are n (%), minor allele frequency (95% CI), and OR (95% CI). P values compare differences in genotype distribution between normally glucose-tolerant individuals and patients with type 2 diabetes applying an additive logistic regression model adjusted for sex and age (*) or sex, age and BMI (†).