Table 3. Relationship Between Hormonal Dysregulation and All-Cause Mortality in Older Men: Adjusted Analysis^a.

Characteristic	Hazard Ratio (95% Confidence Interval)	P Valueb	P Value for Trendc
Bioavailable testosterone <70 ng/dLd	1.48 (0.89-2.46)	.13	.48
Insulinlike growth factor 1 <63.86 ng/mLd	1.36 (0.78-2.38)	.28	.91
Dehydroepiandrosterone sulfate <50 μg/dLd	1.38 (0.84-2.26)	.21	.97
Multiple hormonal dysregulatione			<.001
0 (n=207)
1 (n=106)	1.04 (0.56-1.95)	.89
2 (n=57)	1.34 (0.67-2.65)	.41
3 (n=20)	2.44 (1.09-5.46)	.03

^aResults reported in the table are from separate, fully adjusted models.

^bP values adjusted for age, body mass index, cancer, log(interleukin 6), education, cognitive function, depression, physical activity, caloric and alcohol intake, smoking, coronary heart disease (including angina and myocardial infarction), congestive heart failure, stroke, diabetes hypertension, Parkinson disease, peripheral artery disease, asthma, cancer, and chronic obstructive pulmonary disease.

^cObtained by fitting the same model with hormone levels as continuous variables.

^dTop level of the lowest quartile.

^eHormones in the lowest quartile.